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Role of the CTCF/p300 axis in osteochondrogenic-like differentiation of polyploid giant cancer cells with daughter cells

15 Nov 2024

Abstract excerpt

BACKGROUND: Polyploid giant cancer cells (PGCCs) have properties of cancer stem cells (CSCs). PGCCs with daughter cells (PDCs) undergo epithelial-mesenchymal transition and show enhanced cellular plasticity. This study aimed to elucidate the mechanisms underlying the osteo/chondrogenic-like differentiation of PDCs, which may be exploited therapeutically by transdifferentiation into post-mitotic and functional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39548585
DOI: 10.1186/s12964-024-01933-y

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