Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage

5 Jan 2024

Abstract excerpt

Glioblastoma (GBM) is one of the most aggressive and deadly brain tumors; however, its current therapeutic strategies are limited. Selenoprotein P (SeP; SELENOP, encoded by the SELENOP gene) is a unique selenium-containing protein that exhibits high expression levels in astroglia. SeP is thought to be associated with ferroptosis sensitivity through the induction of glutathione peroxidase 4 (GPX4) via selenium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Selenium in Biological Systems
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38182643
DOI: 10.1038/s41598-024-51259-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storagePMID 38182643Read ↗

GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in GliomaSemantic proximity Read ↗

Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated FerroptosisSemantic proximity Read ↗

Metabolism of Selenium, Selenocysteine, and Selenoproteins in Ferroptosis in Solid Tumor CancersSemantic proximity Read ↗

Downregulated ferroptosis‐related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastomaSemantic proximity Read ↗

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistanceSemantic proximity Read ↗

GPX4: old lessons, new featuresSemantic proximity Read ↗

Selenoprotein GPX1 is a Prognostic and Chemotherapy-related Biomarker for Brain Lower Grade GliomaSemantic proximity Read ↗

Glioblastoma Relapses Show Increased Markers of Vulnerability to FerroptosisSemantic proximity Read ↗

GPX4, ferroptosis, and diseasesSemantic proximity Read ↗

GPX7 is Identified as a Novel Prognostic Indicator for Brain Lower Grade Glioma (LGG): Evidence from a Pan-Cancer AnalysisSemantic proximity Read ↗

Investigation into the Effect and Mechanism of Temozolomide (TMZ) Inducing Ferroptosis to Inhibit Glioma Cell ProliferationSemantic proximity Read ↗

Temozolomide (TMZ) Inhibits Glioma Cell Proliferation by Inducing Ferroptosis: Effect and MechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.