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Nicotine exposure impairs germ cell development in human fetal ovaries cultured in vitro

12 Jul 2018

Abstract excerpt

resulted in the marked increase of apoptosis in the ovaries in a time and dose-dependent manner. Evidence that adverse nicotine effects are potentially due to an increased level of reactive oxygen species (ROS) and consequent DNA damage, both in the ovarian somatic cells and germ cells, are reported. After 4 days of culture, exposure to 1 mM and 10 mM nicotine caused a 50% and 75% decrease, respectively, in the...

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PMID: 30001218
DOI: 10.18632/aging.101492

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