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Article

Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection

2 Nov 2018

Abstract excerpt

Significance Drug-resistant subpopulations of microbes or tumor cells are difficult to detect but can confound disease treatment. In this deep characterization of a chronic fungal infection, we report unprecedented heterogeneity in the drug resistance-related gene MRR1 among Clavispora ( Candida ) lusitaniae isolates from a single individual. Cells expressing Mrr1 variants that led to drug resistance, by elevated...

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PMID: 30389707
DOI: 10.1073/pnas.1807698115

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