Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.

doi:10.1007/s11684-024-1082-6

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Article

Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer.

Frontiers of medicine - 1 Oct 2024

Lu Qixuan, Ren Ningxin, Chen Hongxia, Zhang Shaosen, Yan Ruoqing, Li Mengjie, Zheng Linlin, Tan Wen, Lin Dongxin

Abstract excerpt

Identifying biomarkers for predicting radiotherapy efficacy is crucial for optimizing personalized treatments. We previously reported that rs1553867776 in the miR-4274 seed region can predict survival in patients with rectal cancer receiving postoperative chemoradiation therapy. Hence, to investigate the molecular mechanism of the genetic variation and its impact on the radiosensitivity of colorectal cancer...

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PMID: 39190270
DOI: 10.1007/s11684-024-1082-6

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