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E3 ligase MG53 suppresses tumor growth by degrading cyclin D1

7 Jul 2023

Abstract excerpt

Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregulation of ubiquitination-dependent degradation of cyclin D1 contributes to not only the pathogenesis of malignancies but also the refractory to cancer treatment regiments with CDK4/6 inhibitors. Here we show...

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PMID: 37414783
DOI: 10.1038/s41392-023-01458-9

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