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TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer

13 Apr 2025

Abstract excerpt

Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) suppressed ferroptosis and induced chemoresistance in GC cells. Mechanistically, TMEM160 recruited the E3 ligase TRIM37 to promote K48-linked ubiquitination and degradation of KEAP1, thereby activating NRF2 and...

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PMID: 40223081
DOI: 10.1038/s41419-025-07621-0

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