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Article

PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes.

Nucleic acids research - 6 Jan 2025

Tremmel Roman, Zhou Yitian, Camara Mahamadou D, Laarif Sofiene, Eliasson Erik, Lauschke Volker M

Abstract excerpt

Genetic polymorphisms in drug metabolizing enzymes, drug transporters as well as in genes encoding the human major histocompatibility complex contribute to inter-individual differences in drug efficacy and safety. The extent, pattern and complexity of such pharmacogenetic variation differ drastically across human populations. Here, we present PharmFreq, a global repository of pharmacogenetic frequency information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39540424
DOI: 10.1093/nar/gkae1016
PMCID: PMC11701539

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