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Article

Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.

Open biology - 1 Nov 2024

Moscoso-Romero Esteban, Moro Sandra, Duque Alicia, Yanguas Francisco, Valdivieso M-Henar

Abstract excerpt

Exomer is a protein complex that facilitates trafficking between the Golgi and the plasma membrane (PM). Schizosaccharomyces pombe exomer is composed of Cfr1 and Bch1, and we have found that full activation of the cell integrity pathway (CIP) in response to osmotic stress requires exomer. In the wild-type, the CIP activators Rgf1 (Rho1 GEF) and Pck2 (PKC homologue) and the MEK kinase Mkh1 localize in the PM,...

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Identifiers

PMID: 39540318
DOI: 10.1098/rsob.240101
PMCID: PMC11561738

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