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Article

Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast.

Cellular signalling - 1 Apr 2008

Barba Gregorio, Soto Teresa, Madrid Marisa, Núñez Andrés, Vicente Jeronima, Gacto Mariano, Cansado José

Abstract excerpt

MAPK Pmk1p is the central element of a cascade involved in the maintenance of cell integrity and other functions in Schizosaccharomyces pombe. Pmk1p becomes activated by multiple stressing situations and also during cell separation. GTPase Rho2p acts upstream of the protein kinase C homolog Pck2p to activate the Pmk1 signalling pathway through direct interaction with MAPKKK Mkh1p. In this work we analyzed the...

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Identifiers

PMID: 18255266
DOI: 10.1016/j.cellsig.2007.12.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast.PMID 18255266Read ↗

Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.Semantic proximity Read ↗

The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.Semantic proximity Read ↗

Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.Semantic proximity Read ↗

Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.Semantic proximity Read ↗

Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Geranylgeranyltransferase Cwg2-Rho4/Rho5 module is implicated in the Pmk1 MAP kinase-mediated cell wall integrity pathway in fission yeast.Semantic proximity Read ↗

Rho5p downregulates the yeast cell integrity pathway.Semantic proximity Read ↗

The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway.Semantic proximity Read ↗

The Rgd1p Rho GTPase-activating protein and the Mid2p cell wall sensor are required at low pH for protein kinase C pathway activation and cell survival in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.Semantic proximity Read ↗

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