Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c: A gene-environment interaction study.

doi:10.1016/j.diabres.2024.111927

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Article

Adequate sleep duration accentuates the effect of glucagon-like peptide-1 receptor variant on HbA1c: A gene-environment interaction study.

Diabetes research and clinical practice - 1 Dec 2024

Wei Jiahe, Wu Hanzhang, Zheng Ying, Wang Ningjian, Benedict Christian, Chen Wei, Tan Xiao

Abstract excerpt

BACKGROUND: Both glucagon-like peptide-1 receptor (GLP1R) agonists and lifestyle modifications are widely adopted in managing glycemia. However, the joint effects of GLP1R agonists with lifestyle on glycemic traits have not been evaluated. METHODS: This gene-environment study tested the interaction between GLP1R-rs10305492 variant, consistent with the effect of GLP1R agonist therapies, and four lifestyle factors...

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PMID: 39536975
DOI: 10.1016/j.diabres.2024.111927

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