Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers.

doi:10.1016/j.jchf.2024.08.019

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Article

Cardiovascular Risk Factors and Genetic Risk in Transthyretin V142I Carriers.

JACC. Heart failure - 1 Jan 2025

Shetty Naman S, Gaonkar Mokshad, Pampana Akhil, Patel Nirav, Morrison Alanna C, Reiner Alexander P, Carson April P, Yu Bing, Psaty Bruce M, Kooperberg Charles, Fatkin Diane, Boerwinkle Eric, Rotter Jerome I, Taylor Kent D, Hou Lifang, Irvin Marguerite R, Hall Michael E, Maurer Mathew, Fornage Myriam, Armstrong Nicole D, Bart Nicole, Goyal Parag, Rich Stephen S, Vasan Ramachandran S, Li Peng, Arora Garima, Arora Pankaj

Abstract excerpt

BACKGROUND: Nearly 3% to 4% of Black individuals in the United States carry the transthyretin V142I variant, which increases their risk of heart failure. However, the role of cardiovascular (CV) risk factors (RFs) in influencing the risk of clinical outcomes among V142I variant carriers is unknown. OBJECTIVES: This study aimed to assess the impact of CV RFs on the risk of heart failure in V142I carriers. METHODS:...

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PMID: 39520444
DOI: 10.1016/j.jchf.2024.08.019
PMCID: PMC13229499

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