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Article

Rosa canina L. Methanol Extract and Its Component Rutin Reduce Cholesterol More Efficiently than Miglustat in Niemann-Pick C Fibroblasts.

International journal of molecular sciences - 22 Oct 2024

Wanes Dalanda, Al Aoua Sherin, Shammas Hadeel, Walters Friederike, Das Anibh M, Rizk Sandra, Naim Hassan Y

Abstract excerpt

Niemann-Pick type C (NPC) disease is an autosomal recessive lysosomal storage disorder where 95% of the cases are caused by mutations in the Niemann-Pick C1 (NPC1) gene. Loss of function in NPC1 mutants trigger the accumulation of cholesterol in late endo-lysosomes and lysosomal dysfunction. The current study examined the potential of polyphenol-rich methanol extracts from Rosa canina L. (RCME) and two of its...

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PMID: 39518914
DOI: 10.3390/ijms252111361
PMCID: PMC11547104

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