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Article

Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5.

Experimental & molecular medicine - 1 Nov 2024

Gong Jiali, Li Xiawei, Feng Zengyu, Lou Jianyao, Pu Kaiyue, Sun Yongji, Hu Sien, Zhou Yizhao, Song Tianyu, Shangguan Meihua, Zhang Kai, Lu Wenjie, Dong Xin, Wu Jian, Zhu Hong, He Qiaojun, Xu Hongxia, Wu Yulian

Abstract excerpt

A rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-onset diabetes (PCAND). In the present study, we identified a gene SRI, which possesses a SNP with the potential to distinguish PCAND and Type 2 diabetes mellitus (T2DM), by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39516378
DOI: 10.1038/s12276-024-01346-4
PMCID: PMC11612510

Genes

CCL5
PC
STAT3
SRI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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