Article

A new machine learning based computational framework identifies therapeutic targets and unveils influential genes in pancreatic islet cells

2022-05-01

Abstract excerpt

Pancreatic islets comprise a group of cells that produce hormones regulating blood glucose levels. Particularly, the alpha and beta islet cells produce glucagon and insulin to stabilize blood glucose. When beta islet cells are dysfunctional, insulin is not secreted, inducing a glucose metabolic disorder. Identifying effective therapeutic targets against the disease is a complicated task and is not yet conclusive....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10e368d6-09f2-53a3-8eb9-6df47e377559
DOI: 10.1101/2022.05.01.490186

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A new machine learning based computational framework identifies therapeutic targets and unveils influential genes in pancreatic islet cellsDOI 10.1101/2022.05.01.490186Read

Construction of a prognostic model with histone modification-related genes and identification of potential drugs in pancreatic cancerSemantic proximity Read

Identification, analysis, and drug prediction of key genes related to endoplasmic reticulum stress in pancreatitisSemantic proximity Read

Gene expression analysis reveals diabetes-related gene signaturesSemantic proximity Read

Robust identification of shared key genomic biomarkers for diagnosis and therapies of pancreatic cancer with type-2 diabetesSemantic proximity Read

Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression AnalysisSemantic proximity Read

Identification of key anoikis-related genes and immune cell infiltration characteristics in T2DM based on integrating bioinformatic analysis and machine learningSemantic proximity Read

6-gene machine learning-found signature for the differentiation of pancreatic ductal carcinoma and chronic pancreatitis patients on peripheral blood mononuclear cells RNA-Seq dataSemantic proximity Read

Machine Learning-Driven Discovery of Biomarkers in Gastric Cancer: A Focus on DPT, FBP2, ADH7, INHBA, and GPR155Semantic proximity Read

Analysis of Immune Cell Infiltration Characteristics in Severe Acute Pancreatitis through Integrated BioinformaticsSemantic proximity Read

Detailed transcriptome atlas of the pancreatic beta cellSemantic proximity Read

A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysisSemantic proximity Read

A Neural Network Model to Screen Feature Genes for Pancreatic CancerSemantic proximity Read