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Genetic Alterations in Chromatin Regulatory Genes in Upper Tract Urothelial Carcinoma and Urothelial Bladder Cancer.

Cancer medicine - 1 Nov 2024

Wang Shuo, Yan Xuzhi, Lan Weihua, Wang Yapeng, Wang Ze, Tong Dali, Zhang Yao, Ran Qiang, Li Haoyang, Jin Junhao, Xiao Haiyang, Xu Jing, Yan Qian, Zhang Dianzheng, Ma Qiang, Xiao Hualiang, Qin Jun, Wang Luofu, Jiang Jun, Liu Qiuli

Abstract excerpt

PURPOSE: Upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB) share histomorphological and therapeutic features but distinct epidemiologic and clinicopathologic characteristics. We examined alterations of chromatin regulatory genes in molecular subtypes, clonal relatedness, and T-cell receptor (TCR) diversity in UTUC and UCB. MATERIALS AND METHODS: Targeted next-generation...

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PMID: 39513266
DOI: 10.1002/cam4.70398
PMCID: PMC11544325

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