KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration.

doi:10.1200/PO.24.00329

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Article

KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration.

JCO precision oncology - 1 Nov 2024

Moretto Roberto, Rossini Daniele, Murgioni Sabina, Ciracì Paolo, Nasca Vincenzo, Germani Marco Maria, Calegari Maria Alessandra, Vetere Guglielmo, Intini Rossana, Taravella Ada, Studiale Vittorio, Boccaccio Chiara, Passardi Alessandro, Tamburini Emiliano, Zaniboni Alberto, Salvatore Lisa, Pietrantonio Filippo, Lonardi Sara, Masi Gianluca, Cremolini Chiara

Abstract excerpt

PURPOSE: KRASG12D mutation (mut) occurs in about 10%-12% of metastatic colorectal cancer (mCRC). Recently, novel KRASG12D inhibitors have been developed and are currently under investigation in phase I/II clinical trials in solid tumors including mCRC. We aimed at performing a comprehensive characterization of clinical, molecular, immunologic, and prognostic features of KRASG12D-mutated mCRC to inform the design...

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Identifiers

PMID: 39509668
DOI: 10.1200/PO.24.00329

Genes

KRAS
NRAS
PIK3CA
PTEN

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