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Incorporating traditional and emerging biomarkers in the clinical management of metastatic colorectal cancer: an update.

Expert review of molecular diagnostics - 1 Jul 2020

Baraibar Iosune, Ros Javier, Mulet Nuria, Salvà Francesc, Argilés Guillem, Martini Giulia, Cuadra José Luis, Sardo Emilia, Ciardiello Davide, Tabernero Josep, Élez Elena

Abstract excerpt

INTRODUCTION: Molecular profiling has led to significantly longer survival in metastatic colorectal cancer (mCRC) patients. Clinical guidelines recommend testing for KRAS/NRAS, BRAF and MSI status, and new biomarkers such as HER2 amplification and NTRK fusions have emerged more recently in refractory CRC, supported by overwhelming clinical relevance. These biomarkers can guide treatment management to improve...

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PMID: 32552041
DOI: 10.1080/14737159.2020.1782194

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