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Article

Translational Relevance of the Genomic Landscape of KRASG12D-Mutant Colorectal and Pancreatic Cancers.

Targeted oncology - 1 Jan 2026

Jazieh Khalid, Tsai Jill, Solomon Sheila, Zhu Mojun, Pedersen Katrina S, Fernandez-Zapico Martin E, Xie Hao

Abstract excerpt

BACKGROUND: KRASG12D is one of the most prevalent driver mutations in patients with pancreatic ductal adenocarcinoma (PDAC) and colorectal adenocarcinoma (CRC). Although this genetic alteration is associated with poor prognosis and resistance to chemotherapy, additional genomic features may contribute to the behavior of KRAS-mutant PDACs and CRCs. OBJECTIVE: Here, we aimed at defining the landscape of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41372636
DOI: 10.1007/s11523-025-01191-z

Genes

KRAS
BRAF
EGFR
NRAS
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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