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Article

A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background.

Journal of ovarian research - 6 Nov 2024

Narayanan Aravindan, More Ankita S, Talreja Muskan, Mali Avinash M, Vinay Sannannagari Boya, Bapat Sharmila A

Abstract excerpt

BACKGROUND: Transcript variants and protein isoforms are central to unique tissue functions and maintenance of homeostasis, in addition to being associated with aberrant states such as cancer, where their crosstalk with the mutated tumor suppressor p53 may contribute to genomic instability and chromosomal rearrangements. We previously identified several novel splice variants in ovarian cancer RNA-sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39506768
DOI: 10.1186/s13048-024-01538-6
PMCID: PMC11539462

Genes

ITGB8

Provenance

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