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Bioinformatic Analysis of the Structural Features of the H106P/N137A Mutant as a Potential Vaccine Candidate Against Clostridium perfringens.

Clinical laboratory - 1 Nov 2024

Nakhaipour Elmira, Alimolaei Mojtaba, Kariminik Ashraf, Bafti Mehrdad S

Abstract excerpt

BACKGROUND: The complex and expensive processes involved in the production of current clostridial toxoid vaccines require the design of new methods. The aim of this study was to introduce single and combined nontoxic mutants of Clostridium perfringens epsilon toxin (ETX) into the vaccine production. METHODS: Antigenic properties, amino acid sequence, physicochemical characteristics, stability, and protein...

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PMID: 39506593
DOI: 10.7754/Clin.Lab.2024.240220

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