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A Pilot Study on BRCA1/2 and PI3K Mutations Across Subtypes of Triple Negative Breast Cancer in North Indian Population.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2024

Gupta Parul, Thakur Tamanna, Chadda Anjali, Irinike Santosh, Khare Siddhant, Bal Amanjit

Abstract excerpt

BRCA1/2 are tumor suppressor genes which regulate the DNA repair mechanism. Mutations in BRCA1/2 may increase the risk of breast cancer in patients. In the present study frequency of BRCA1/2 mutations in triple negative breast cancer (TNBC) patients was assessed and correlated with molecular subtypes of TNBC. Blood samples from 65 confirmed cases of TNBC were collected. DNA was isolated from whole blood and...

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Identifiers

PMID: 39506289
DOI: 10.1097/PAI.0000000000001231

Genes

BRCA1
BRCA2
AR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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