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Article

Effect of NK cell receptor genetic variation on allogeneic stem cell transplantation outcome and in vitro NK cell cytotoxicity.

Scientific reports - 6 Nov 2024

Nihtilä Julia, Penna Leena, Salmenniemi Urpu, Itälä-Remes Maija, Crossland Rachel E, Gallardo David, Bogunia-Kubik Katarzyna, Lacina Piotr, Bieniaszewska Maria, Giebel Sebastian, Karjalainen Katariina, Jahan Farhana, Kerkelä Erja, Hyvärinen Kati, Koskela Satu, Ritari Jarmo, Partanen Jukka

Abstract excerpt

Natural killer (NK) cells recognize and may kill malignant cells via their cell surface receptors. Killer cell immunoglobulin-like receptor (KIR) genotypes of donors have been reported to adjust the risk of relapse after allogeneic stem cell transplantation (HSCT), particularly in patients with acute myeloid leukemia. To test whether non-KIR NK cell receptors have a similar effect, we screened 1,638 genetic...

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Share to Cytotoxicity, Immunologic
Share to Graft vs Host Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Killer Cells, Natural

Share to Leukemia, Myeloid, Acute

Share to Receptors, Natural Killer Cell

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Share to Transplantation, Homologous

Source

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Identifiers

PMID: 39506082
DOI: 10.1038/s41598-024-78619-5
PMCID: PMC11541542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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