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Article

Plausible, robust biological oscillations through allelic buffering.

Cell systems - 20 Nov 2024

Hsieh Feng-Shu, Nguyen Duy P M, Heltberg Mathias S, Wu Chia-Chou, Lee Yi-Chen, Jensen Mogens H, Chen Sheng-Hong

Abstract excerpt

Biological oscillators can specify time- and dose-dependent functions via dedicated control of their oscillatory dynamics. However, how biological oscillators, which recurrently activate noisy biochemical processes, achieve robust oscillations remains unclear. Here, we characterize the long-term oscillations of p53 and its negative feedback regulator Mdm2 in single cells after DNA damage. Whereas p53 oscillates...

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PMID: 39504970
DOI: 10.1016/j.cels.2024.10.002

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MDM2

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