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Article

Association between toxin-antitoxin system mutations and global transmission of MDR-TB.

BMC infectious diseases - 5 Nov 2024

Li Yameng, Shao Yang, Li Yifan, Kong Xianglong, Tao Ningning, Hou Yawei, Wang Tingting, Li Yingying, Liu Yao, Li Huaichen

Abstract excerpt

BACKGROUND: The emergence of Multidrug-Resistant Tuberculosis (MDR-TB) poses a significant threat to global tuberculosis control efforts. This study aimed to examine the influence of mutations in Toxin-Antitoxin system genes on the global transmission of MDR-TB caused by Mycobacterium tuberculosis (M. tuberculosis). METHODS: Whole-genome sequencing was conducted on 13,518 M. tuberculosis isolates. Genes of the...

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Identifiers

PMID: 39501228
DOI: 10.1186/s12879-024-10142-4
PMCID: PMC11539496

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