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Comparative in silico analysis of vapBC3 toxin-antitoxin system in Mycobacterium Bovis and Mycobacterium tuberculosis.

Scientific reports - 19 Nov 2025

Shafipour Maryam, Mohammadzadeh Abdolmajid, Tabrizi Gholamhossein Farrokhpour, Mahmoodi Pezhman, Ghaemi Ezzat Allah

Abstract excerpt

Toxin-Antitoxin (TA) systems are highly conserved genetic elements in the Mycobacterium tuberculosis complex, playing a critical role in bacterial survival, stress response, and persistence. Small variations in sequence composition can lead to species-specific functional differences, potentially influencing host adaptation, antibiotic tolerance, and virulence strategies. In this study, a comparative analysis of...

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PMID: 41258227
DOI: 10.1038/s41598-025-24448-z
PMCID: PMC12630944

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