Respiratory chain gene mutations associated with global phylogenetic clustering of drug-resistant Mycobacterium tuberculosis revealed by whole-genome sequencing.

Abstract excerpt

Background: The regulatory mechanism of respiratory chain in Mycobacterium tuberculosis (M. tuberculosis) remains to be elucidated, and limited evidence about the effect of gene mutations in the respiratory chain on multidrug-resistant (MDR) isolates was reported. Objective: To elucidated the effect of gene mutations in the respiratory chain on MDR isolates. Methods: Whole-genome sequencing was performed on...

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