Article
A Novel One-Sample Mendelian Randomization Approach for Count-Type Outcomes That Is Robust to Correlated and Uncorrelated Pleiotropic Effects.
Genetic epidemiology - 1 Jan 2025
Liyanage Janaka S S, Hankins Jane S, Estepp Jeremie H, Srivastava Deokumar, Rashkin Sara R, Takemoto Clifford, Li Yun, Cui Yuehua, Mori Motomi, Weiss Mitchell J, Kang Guolian
Abstract excerpt
We propose two novel one-sample Mendelian randomization (MR) approaches to causal inference from count-type health outcomes, tailored to both equidispersion and overdispersion conditions. Selecting valid single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) poses a key challenge for MR approaches, as it requires meeting the necessary IV assumptions. To bolster the proposed approaches by...
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