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Traumatic Stress and Human DNA Methylation: A Critical Review

1 Jun 2015

Abstract excerpt

Animal studies have identified persistent and functional effects of traumatic stress on the epigenome. This review discusses the clinical evidence for trauma-induced changes in DNA methylation across the life span in humans. Studies are reviewed based on reports of trauma exposure during the prenatal period (13 studies), early life (20 studies), and adulthood (ten studies). Even though it is apparent that...

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PMID: 26111031
DOI: 10.2217/epi.15.11

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