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Article

Routine laboratory screening for cyp51a-related azole resistance in Aspergillus fumigatus using Etest: Concordance with gene sequencing.

Medical mycology - 12 Nov 2024

Rabault Charlotte, Rakotoarivony Yann, Houzé Sandrine, Bonnal Christine, Joste Valentin

Abstract excerpt

We evaluated the combined performance of itraconazole and voriconazole Etest® gradient concentration strips for the detection of Aspergillus fumigatus azole resistance associated with cyp51a mutations confirmed by gene sequencing. Among 118 A. fumigatus clinical isolates collected in a French center, 6 (5%) had azole resistance mutations, 5 of which were probably of environmental origin. Using recent...

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PMID: 39479789
DOI: 10.1093/mmy/myae107

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