Causal association of cholesterol metabolism-related proteins with hepatocellular carcinoma and dysfunction-associated steatotic liver disease: a mendelian randomization study

Abstract excerpt

BACKGROUND: Dysregulation of cholesterol metabolism has been recognized as a critical driver in the pathogenesis of hepatic disorders, particularly hepatocellular carcinoma (HCC) and metabolic dysfunction-associated steatotic liver disease (MASLD). However, the causal relationships between circulating proteins involved in cholesterol homeostasis and the progression of these hepatopathologies remain insufficiently...

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