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Article

Association Between ABCC2 -24C>T and Nab-Paclitaxel-induced Peripheral Neuropathy in Japanese Patients With Pancreatic Cancer.

Anticancer research - 1 Nov 2024

Nakayama Hana, Ishida Hiroo, Iidaka Masanori, Kato Shoko, Nakatani Kei, Nakayama Akihiro, Noguchi Toshihiro, Nishihara Shigetoshi, Oikawa Shu, Usami Tomono, Mitsui Yuta, Ishii Y U, Toshima Hirokazu, Kobayashi Kouji, Murase Remi, Matsumoto Natsumi, Suzuki Kosuke, Shimada Ken, Yoshida Hitoshi, Fujita Ken-Ichi

Abstract excerpt

BACKGROUND/AIM: Nab-paclitaxel is used to treat patients with pancreatic cancer. However, it frequently induces peripheral neuropathy. Notably, pharmacokinetic factors may be associated with neuropathic symptoms as the onset depends on the cumulative dose. Therefore, we prospectively examined the association between the cumulative dose of nab-paclitaxel at the onset of peripheral neuropathy and polymorphisms of...

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PMID: 39477313
DOI: 10.21873/anticanres.17326

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