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Article

PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells.

International journal of molecular sciences - 21 Feb 2022

Shin Won-Sik, Park Mi-Kyung, Kim Jae Hoon, Oh Si Won, Jang Ji-Yun, Lee Ho, Lee Seung-Taek

Abstract excerpt

Protein tyrosine kinase 7 (PTK7), a catalytically defective receptor protein tyrosine kinase, is upregulated in tumor tissues and cell lines of esophageal squamous cell carcinoma (ESCC). We showed that PTK7 plays an oncogenic role in various ESCC cell lines. However, its role as an oncogene has not been demonstrated in vivo. Here, we examined the influence of PTK7 on the tumorigenic potential of ESCC KYSE-30...

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Source

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Identifiers

PMID: 35216506
DOI: 10.3390/ijms23042391
PMCID: PMC8876147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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