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Article

Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathway.

PloS one - 16 Nov 2010

Meng Ling, Sefah Kwame, O'Donoghue Meghan B, Zhu Guizhi, Shangguan Dihua, Noorali Afshan, Chen Yan, Zhou Lei, Tan Weihong

Abstract excerpt

Protein tyrosine kinase-7 (PTK7) is a catalytically inactive receptor tyrosine kinase (RTK). PTK7 is upregulated in many common human cancers, including colon cancer, lung cancer, gastric cancer and acute myeloid leukemia. The reason for this up-regulation is not yet known. To explore the functional role of PTK7, the expression of PTK7 in HCT 116 cells was examined using small interference (siRNA)-mediated gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21103379
DOI: 10.1371/journal.pone.0014018
PMCID: PMC2982840

Genes

PTK7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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