Article
The GG genotype of the serotonin 4 receptor genetic polymorphism, rs1345697, is associated with lower remission rates after antidepressant treatment: Findings from the METADAP cohort.
Journal of affective disorders - 15 Feb 2022
Poinsignon Vianney, Colle Romain, Asmar Khalil El, Mendez-David Indira, David Denis J, Ait Tayeb Abd El Kader, Chappell Kenneth, Gressier Florence, Herrero Hugo, Fève Bruno, Becquemont Laurent, Corruble Emmanuelle, Verstuyft Céline
Abstract excerpt
BACKGROUND: Pharmacological studies have yielded valuable insights into the role of the serotonin 4 receptor (HTR4) in major depressive episodes (MDE) and response to antidepressant drugs (AD). A genetic association has been shown between HTR4 and susceptibility to mood disorders. Our study aims at assessing the association between the HTR4 genetic polymorphism, rs1345697, and improvement in depressive symptoms...
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