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Article

Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses.

BMC medical genomics - 5 Dec 2016

Chen Haifen, Zhou Xinrui, Zheng Jie, Kwoh Chee-Keong

Abstract excerpt

BACKGROUND: The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a glycoprotein on the surface of the virus), which enables the virus population to constantly evade the human immune system. Therefore, the vaccine has to be updated every year to stay effective. There is a need to characterize the evolution of influenza viruses for better selection of vaccine candidates and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28117657
DOI: 10.1186/s12920-016-0230-5
PMCID: PMC5260787

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