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α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway

17 Oct 2024

Abstract excerpt

Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence and thereby contribute to aging. Therefore, protecting telomeres from DNA damage is essential in order to avoid entry into senescence and...

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Circadian rhythm and melatonin
Genetics, Aging, and Longevity in Model Organisms
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39456511
DOI: 10.3390/antiox13101258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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