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Impact of met-haemoglobin and oxidative stress on endothelial function in patients with transfusion dependent β-thalassemia

25 Oct 2024

Abstract excerpt

Transfusion dependent β-thalassemia is a genetic blood disorder characterized by chronic anaemia. Blood transfusion is lifesaving but comes at a cost. Iron overload emerges as a prime culprit as a free radicals damage endothelial cells. Chronic anaemia further disrupts oxygen delivery, exacerbating the oxidative stress. Increased levels of met-haemoglobin and malondialdehyde compromise endothelial function. This...

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PMID: 39455629
DOI: 10.1038/s41598-024-74930-3

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