Pathophysiology and treatment of patients with beta-thalassemia – an update

Abstract excerpt

Thalassemia (thal) is an autosomal recessive, hereditary, chronic hemolytic anemia due to a partial or complete deficiency in the synthesis of α-globin chains (α-thal) or β-globin chains (β-thal) that compose the major adult hemoglobin (α 2 β 2). It is caused by one or more mutations in the corresponding genes. The unpaired globin chains are unstable; they precipitate intracellularly, resulting in hemolysis, prema...

Topics

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• beta-Globins
• beta-Thalassemia
• Clinical Decision-Making
• Combined Modality Therapy
• Disease Management
• Disease Susceptibility
• Incidence
• Severity of Illness Index

Identifiers and source

Literature Corpus work

590dfb00-4a64-540e-a053-364d0aa923de

DOI

10.12688/f1000research.12688.1