Article
Allogenic MSC infusion in kidney transplantation recipients promotes within 4 hours distinct B cell and T cell phenotypes.
Frontiers in immunology - 1 Jan 2024
Hendriks Sanne H, Heidt Sebastiaan, Reinders Marlies E J, Koning Frits, van Kooten Cees
Abstract excerpt
Background: Infusion of mesenchymal stromal cells (MSCs) has been proposed as immune-modulatory therapy in solid organ transplantation. The use of allogenic MSCs could improve standardization and allow for direct availability of the product. Method: The nonrandomized phase Ib Neptune clinical trial provided safety and feasibility data on the use of allogenic bone-marrow-derived MSCs, infused in 10 patients at...
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