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Article

Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction.

GeroScience - 1 Apr 2025

Engvig Andreas, Kalleberg Karl Trygve, Westlye Lars T, Leonardsen Esten Høyland

Abstract excerpt

DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in...

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Identifiers

PMID: 39446224
DOI: 10.1007/s11357-024-01376-w
PMCID: PMC11979055

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