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Predicting amyloid beta accumulation in cognitively unimpaired older adults: Cognitive assessments provide no additional utility beyond demographic and genetic factors

1 Mar 2025

Abstract excerpt

BACKGROUND: Integrating non-invasive measures to estimate abnormal amyloid beta accumulation (Aβ+) is key to developing a screening tool for preclinical Alzheimer's disease (AD). The predictive capability of standard neuropsychological tests in estimating Aβ+ has not been quantified. METHODS: We constructed machine learning models using six cognitive measurements alongside demographic and genetic risk factors to...

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PMID: 40110649
DOI: 10.1002/alz.70036

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