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EP152R ‐mediated endoplasmic reticulum stress contributes to African swine fever virus infection via the PERK ‐ eIF2α pathway

19 Nov 2024

Abstract excerpt

African swine fever virus (ASFV) is a large, icosahedral, double-stranded DNA virus in the Asfarviridae family and the causative agent of African swine fever (ASF). ASFV causes a hemorrhagic fever with high mortality rates in domestic and wild pigs. ASFV contains an open reading frame named EP152R, previous research has shown that EP152R is an essential gene for virus rescue in swine macrophages. However, the...

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PMID: 39560029
DOI: 10.1096/fj.202400931rr

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