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Article

Two-hit model for the development of aldosterone-producing adenoma: supporting from two new cases.

Journal of hypertension - 1 Mar 2025

Gao Yinjie, Wang Yu, Zhou Yue, Ding Jie, Chang Xiaoyan, Qiu Ling, Huo Li, Wen Jin, Zhang Yushi, Tong Anli

Abstract excerpt

Recently, a two-hit model for the development of aldosterone-producing adenoma (APA) was proposed but until now, only two cases supporting the model have been reported. Here, we present two new cases of primary aldosteronism (PA), both of which had large functional adenomas with somatic mutations in aldosterone-driving genes. Furthermore, the first patient, who had a history of colorectal cancer, was found to...

Read the complete abstract on PubMed

Topics

Humans
Aldosterone
Middle Aged
Hyperaldosteronism
Male
Adenoma
beta Catenin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Adrenocortical Adenoma

Mutation

Adrenal Cortex Neoplasms

Cell Proliferation

Source

Identifiers

PMID: 39445622
DOI: 10.1097/HJH.0000000000003888

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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