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Recent Advances in Mitochondrial Aminoacyl-tRNA Synthetases and Disease.

Trends in molecular medicine - 1 Aug 2017

Sissler Marie, González-Serrano Ligia Elena, Westhof Eric

Abstract excerpt

Dysfunctions in mitochondria - the powerhouses of the cell - lead to several human pathologies. Because mitochondria integrate nuclear and mitochondrial genetic systems, they are richly intertwined with cellular activities. The nucleus-encoded mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) are key components of the mitochondrial translation apparatus. Mutations in these enzymes predominantly affect the...

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PMID: 28716624
DOI: 10.1016/j.molmed.2017.06.002

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