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Frameshift Mutations in Genes Encoding PBP3 and PBP4 Trigger an Unusual, Extreme β-Lactam Resistance Phenotype in Burkholderia multivorans.

ACS infectious diseases - 8 Nov 2024

Mojica Maria F, Nukaga Michiyoshi, Becka Scott A, Zeiser Elise T, Hoshino Tyuji, LiPuma John J, Papp-Wallace Krisztina M

Abstract excerpt

In our curated panel of Burkholderia cepacia complex isolates, Burkholderia multivorans strain AU28442 was unusually highly β-lactam resistant. To explore the molecular mechanisms leading to this phenotype, we performed whole genome sequencing (WGS) and microbiological and biochemical assays. WGS analysis revealed that strain AU28442 produced two β-lactamases, AmpC22 and a novel PenA-like β-lactamase denominated...

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PMID: 39440926
DOI: 10.1021/acsinfecdis.4c00330

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