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Article

Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Malott Rebecca J, Steen-Kinnaird Barbara R, Lee Tracy D, Speert David P

Abstract excerpt

A major challenge to clinical therapy of Burkholderia cepacia complex (Bcc) pulmonary infections is their innate resistance to a broad range of antimicrobials, including polycationic agents such as aminoglycosides, polymyxins, and cationic peptides. To identify genetic loci associated with this phenotype, a transposon mutant library was constructed in B. multivorans ATCC 17616 and screened for increased...

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Identifiers

PMID: 22006009
DOI: 10.1128/AAC.00602-11
PMCID: PMC3256039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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