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ACE and ACE2 activities and polymorphisms assessment: A populational study from Ipaussu (SP, Brazil) during the COVID-19 pandemic.

Life sciences - 1 Dec 2024

Dos Santos Lilian, Favaroni Mendes Salgado Ribeiro Lys Angela, Febba Gomes Andréia Cristina, Azinheira Nobrega Cruz Nayara, Gonçalves de Oliveira Lilian Caroline, Cenedeze Marcos Antonio, Tedesco Silva Junior Hélio, Medina Pestana José Osmar, Casarini Dulce Elena

Abstract excerpt

AIM: The angiotensin-converting enzyme 2 (ACE2) and its homolog, the angiotensin converting enzyme 1 (ACE), are involved in COVID-19 physiopathology. Alterations in the enzymatic structure, expression, and/or activity may influence the risk of infection and severity of disease. For this reason, we aimed to identify different allelic forms of ACE2 G8790A and ACE I/D polymorphisms in a Brazilian cohort and evaluate...

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Identifiers

PMID: 39437850
DOI: 10.1016/j.lfs.2024.123157

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