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Article

Angiotensin-converting-enzyme insertion/deletion polymorphism, ACE activity, and COVID-19: A rather controversial hypothesis. A case-control study.

Journal of medical virology - 1 Mar 2022

Papadopoulou Anna, Fragkou Paraskevi C, Maratou Eirini, Dimopoulou Dimitra, Kominakis Antonis, Kokkinopoulou Ioanna, Kroupis Christos, Nikolaidou Athina, Antonakos Georgios, Papaevangelou Vasiliki, Armaganidis Apostolos, Tsantes Argirios, Polyzogopoulou Eftychia, Tsiodras Sotirios, Antoniadou Anastasia, Moutsatsou Paraskevi

Abstract excerpt

Accumulating data has shown a contribution of the renin-angiotensin system in COVID-19 pathogenesis. The role of angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism as a risk factor in developing COVID-19 disease comes from epidemiological data and is controversially discussed. We conducted a retrospective case-control study and assessed the impact of ACE I/D genotype in COVID-19 disease...

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Identifiers

PMID: 34708878
DOI: 10.1002/jmv.27417
PMCID: PMC8661574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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