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Article

FAM83F regulates canonical Wnt signalling through an interaction with CK1α

24 Dec 2020

Abstract excerpt

The function of the FAM83F protein, like the functions of many members of the FAM83 family, is poorly understood. Here, we show that injection of Fam83f mRNA into Xenopus embryos causes axis duplication, a phenotype indicative of enhanced Wnt signalling. Consistent with this, overexpression of FAM83F activates Wnt signalling, whereas ablation of FAM83F from human colorectal cancer (CRC) cells attenuates it. We...

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PMID: 33361109
DOI: 10.26508/lsa.202000805

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